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Analgesic

Anti - Emetic

Anti - Emetic

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Cyparin -1000

Cyparin -1000

Description:
Paracetamol solution for infusion is a clear and slightly yellowish solution. It contains 10mg/mL of paracetamol. Paracetamol is a white crystalline solid or powder chemically described as 4 - acetaminophen.

Clinical Pharmacology:
Pharmacodynamics
Paracetamol 10 mg/mL, solution for infusion provides onset of pain relief within 5 to 10 minutes after the start of administration. The peak analgesic effect is obtained in 1 hour and the duration of this effect is usually 4 to 6 hours. Paracetamol 10 mg/mL, solution for infusion reduces fever within 30 minutes after the start of administration with a duration of the antipyretic effect of at least 6 hours.

Pharmacokinetics:
Adults
Absorption: Paracetamol pharmacokinetics are linear after a single administration of up to 2 g and after repeated administration during 24 hours.

Distribution:
  • The volume of distribution of paracetamol is approximately 1 L/kg.
  • Paracetamol is not extensively bound to plasma proteins.
  • Following infusion of 2g proparacetamol, (equivalent to 1g of paracetamol) significant concentrations of paracetamol (about 1.5 µg/mL) were observed in the cerebrospinal fluid 20 minutes after infusion.
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      Ganesh Iyer

      (Partner)

      Cygnus Healthcare Specialities Private Limited, Mumbai

      Thane West, Thane, Maharashtra, India

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