|Atc Classification & Description:|
P01BE02 -; Belongs to the class of artemisinin and derivative antimalarials. The chemical name of is (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2benzodioxepine. is a white, crystalline powder that is freely soluble in acetone, soluble in methanol and ethanol, and practically insoluble in water. It has the empirical formula C16H26O5 with a molecular weight of 298.4
/ Lumefantrine is indicated for the treatment of uncomplicated P. falciparum malaria including multi-drug resistant strains of P.falciparum. it is also effective against the blood stage of P.vivax but not active against hypnozoites. / Lumefantrine must be used for the malaria infections acquired in areas where the parasites may be resistant to other anti-malarial drugs
Dosage and administration:
Patients with acute malaria are frequently averse to food. The dose may be encouraged to resume normal eating as soon as food can be tolerated since this improves absorption of and Lumefantrine. In the event of vomiting within 1 hour of administration a repeat dose should be taken.
Acute uncomplicated falciparum malaria
Adult: 80 mg daily, to be taken with lumefantrine 480 mg daily. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6.
Child:Daily doses based on body wt: 5-14 kg: 20 mg with lumefantrine 120 mg; 15-24 kg: 40 mg with lumefantrine 240 mg; 25-34 kg: 60 mg with lumefantrine 360 mg and >34 kg: 80 mg with lumefantrine 480 mg. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr.
Each tablet contains:
Each 5 ml contains:
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